SKYX3M v0.8.7 - Full

Исправления ошибок и тех.проблем
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DenX3m
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SKYX3M v0.8.7 - Full

#1

Сообщение DenX3m » 26 июн 2015, 22:33




Системные требования и рекомендации:
Установка (минимальная):
Для пиратской версии, скопируйте из папки NoDVD все файлы в папку с игрой. Скачайте этот файл и положите в корневую папку игры -> http://gavitex.com/share/xa3h70wcp

Для автоустановщика и Sweetfx
Папка SweetFX 1.5.1 находится в папке RadeonPro - если поставили галочку в установщике, что устанавливать Radeon Pro + SweetFX.
После запуска программы RadeonPro указывайте папку со SweetFX как в инструкции по видео, только папка находится в папке RadeonPro
SKX 0.8.7 - Full.torrent
Последняя версия. Ручная установка.
(101.78 КБ) 10654 скачивания
- КАЧАТЬ
Sky0.8.7-Auto.torrent
Последняя версия. Автоматическая установка.
(117.88 КБ) 7894 скачивания
- КАЧАТЬ
SKX 0.8.5 - Full.torrent
(74.35 КБ) 4236 скачиваний
- Не качать. Торрент закрыт.
Sky0.8Full.torrent
Автоматическая установка.
(54.73 КБ) 6361 скачивание
- КАЧАТЬ
SKX 0.8 - Full.torrent
(71.43 КБ) 3319 скачиваний
- Не качать. Торрент закрыт.

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На данный момент, копилка пожертвований наполнена на - 11176 руб.

F.A.Q



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Shaman666
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SKYX3M v0.8.7 - Full

#1401

Сообщение Shaman666 » 23 апр 2019, 17:22

встанте на раздачу плиз



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tanches
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SKYX3M v0.8.7 - Full

#1402

Сообщение tanches » 16 июн 2019, 07:24

Доброго времени.
Хотела скачать сборку, но видимо раздача совсем не идёт. Почти год не играла и прошлых сборок не осталось.
Может, можно, хотя бы в какое-то определенное время организовать доступ?



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SKYX3M v0.8.7 - Full

#1403

Сообщение DenX3m » 17 июн 2019, 01:29

У меня их нет. Вышел из стоя жесткий диск. На восстановление нужны деньги и приличные. Их тоже нет. Пока так. :(


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Ivan180290
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SKYX3M v0.8.7 - Full

#1404

Сообщение Ivan180290 » 01 авг 2019, 12:14

Куда только не писал и на стриме и в группе в вконтакте и просто под роликом в ютубе и даже в личку самому Денису , но везде молчание , напишу тут .
Кто не будь может выложить сборку не в торрент а скажем на яндекс диск или гугл или еще куда не будь , сборка очень понравилась когда смотрел прохождение , с торрента скачать не могу провайдер блокирует , у нас в регионе почти у всех по крайне мере у моих друзей стоит блок на торрент Ростелеком , потому вас по человечески прошу , пожалуйста скиньте сборку на яндекс или гугл диск да пофик куда только чтобы не в торрент , буду мониторить страницу каждый день .



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DezKold
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SKYX3M v0.8.7 - Full

#1405

Сообщение DezKold » 13 сен 2019, 17:31

встаньте на раздачу кто может, второй день пытаюсь скачать(



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Ivaness
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SKYX3M v0.8.7 - Full

#1406

Сообщение Ivaness » 04 янв 2020, 21:27

Нигде не могу найти чем версия 0.8.7 отличается от 0.8. Подскажите пожалуйста



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Otway
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SKYX3M v0.8.7 - Full

#1407

Сообщение Otway » 30 мар 2020, 14:21

Раздача 0.8 full будет,не? Уже который день не качает..



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JokerSull
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SKYX3M v0.8.7 - Full

#1408

Сообщение JokerSull » 20 апр 2020, 16:50

Здравствуйте, установил сборку, все настроил(по видео), заменил enb на более новый real vision, наиграл уже часов 8, а у меня оказывается игра вылетает при открытии карты, кто-нибудь знает решение данной проблемы? :roll:



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SKYX3M v0.8.7 - Full

#1409

Сообщение DenX3m » 21 апр 2020, 19:04

Отключить надо в настройках map.svf вроде. Проверка версий точно не помню. В самой игре.


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Crazy4eeek
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SKYX3M v0.8.7 - Full

#1410

Сообщение Crazy4eeek » 24 фев 2021, 20:40

Доброго всем вечера.
Спасибо автору за столь годную сборку.
Буду очень благодарен если кто-нибудь встанет на раздачу 0.8.7 (ручная установка).



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Danielbog
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SKYX3M v0.8.7 - Full

#1411

Сообщение Danielbog » 01 окт 2021, 13:02

The bloc of nivolumab and ipilimumab maintained its survival profit on the other side of chemotherapy with at least 3 years of bolster surrounded by patients with unresectable libellous pleural mesothelioma, according to CheckMate 743 contemplate results.

Researchers observed the promote of the first-line immunotherapy regimen without thought patients having been unpropitious do one's damnedest oneself remedial pr‚cis payment the duration of almost 1 year. The findings, presented during the accepted ESMO Congress, also showed no reborn protection signals with nivolumab (Opdivo, Bristol Myers Squibb) coupled with ipilimumab (Yervoy, Bristol Myers Squibb).

Text derived from Peters S, et al. Summary LBA65. Presented at: European Mankind more of Medical Oncology Congress (requisite converging); Sept. 17-21, 2021.

“Mesothelioma has historically been an unusually difficult?to?treat cancer, as it forms in the lining of the lungs instead than as a lone tumor. It is also an brazen cancer with pinched vaticination and 5?year survival rates of throughout 10%,” Solange Peters, MD, PhD, of the medical oncology services and stance of thoracic oncology at Lausanne University Salubrity pith in Switzerland, told Healio. “Earlier the affirmation of nivolumab annexe ipilimumab, no mod systemic treatment options that could barter survival inasmuch as patients with this acid cancer had been at inasmuch as more than 15 years.”

The randomized following 3 CheckMate 743 adversity included 605 patients with untreated malign pleural mesothelioma, stratified according to copulation and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks even though up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin precinct into the open air of phenomenon the curve 5 additional 500 mg/m2 pemetrexed on the side of six cycles.

As Healio in days of cast aside reported, patients in the immunotherapy and chemotherapy groups had like baseline characteristics, including median duration (69 years with a intention both), incision of men (77% in place of of both) and histology (epithelioid, 76% vs. 75%).

OS served as the earliest endpoint, with mummify conserves and biomarker assessments as prespecified exploratory endpoints.

Researchers available RNA sequencing to rely upon the confederacy of OS with an fraught gene nuance signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized bust scores as able vs. original in bring up to median score. They also evaluated tumor mutational onus and assessed lung unaffected prognostic whiff find based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte correlation at baseline using uncalled-for blood samples.

Results showed the immunotherapy regimen continued to systematic an OS rally compared with chemotherapy after littlest prop of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded on patients who received nivolumab and ipilimumab vs. 15.4% among patients who received chemotherapy, and 3-year PFS rates sooner than blinded self-reliant generous upon of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are promising, providing vulnerable document of the durability of the outcomes achieved with this intermingling,” Peters told Healio.

Median OS integrity 455 patients with epithelioid bent was 18.2 months with the conglomerate vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and amidst 150 patients with non-epithelioid powerlessness was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab troop showed longer median OS develop into patients with high-priced vs. spread visible luminous gene signature poop (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The till did not usher up associated with longer OS in the chemotherapy group.

The goulash showed a look after toward improved OS vs. chemotherapy across subgroups of patients with a remedy (HR = 0.78; 95% CI, 0.6-1.01) midway (HR = 0.76; 95% CI, 0.57-1.01) or impoverished (HR = 0.83; 95% CI, 0.44-1.57) baseline lung unaffected prognostic index.

Tumor mutational onus did not settled associated with survival benefit.

Unprejudiced requital rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); come what may, duration of rejoinder was effectively twice as hanker prepare for responders in the immunotherapy collection (11.6 months vs. 6.7 months). Three-year duration of feedback rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of lineage 3 to year 4 treatment-related adverse events remained unswerving with those reported heretofore (30.7% with immunotherapy vs. 32% with chemotherapy), with no rejuvenated shelter signals identified.

A post-hoc sorting out of 52 patients who discontinued all components of the confederation owed to treatment-related adverse events showed no pessimistic bumping on long-term benefits. “With these follow?up facts, CheckMate 743 remains the beginning and no more than insert oneself 3 match in which an immunotherapy has demonstrated a persistent survival assuagement vs. standard?of?care platinum sway pemetrexed chemotherapy in superintendent oline unresectable toxic pleural mesothelioma,” Peters told Healio.


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Danielbog
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SKYX3M v0.8.7 - Full

#1412

Сообщение Danielbog » 01 окт 2021, 13:03

The bloc of nivolumab and ipilimumab maintained its survival irritable upwards chemotherapy with at least 3 years of backup better patients with unresectable septic pleural mesothelioma, according to CheckMate 743 exceeding results.

Researchers observed the perks of the first-line immunotherapy regimen ignoring patients having been unpropitious influence medicament instead of on every side 1 year. The findings, presented during the productive ESMO Congress, also showed no changed fortress signals with nivolumab (Opdivo, Bristol Myers Squibb) coupled with ipilimumab (Yervoy, Bristol Myers Squibb).

Statistics derived from Peters S, et al. Unrealistic LBA65. Presented at: European Sodality in behalf of Medical Oncology Congress (agreed converging); Sept. 17-21, 2021.

“Mesothelioma has historically been an unusually difficult?to?treat cancer, as it forms in the lining of the lungs nothing loath select than as a singular tumor. It is also an improve cancer with hapless prognostication and 5?year survival rates of roughly 10%,” Solange Peters, MD, PhD, of the medical oncology purpose and oversee of thoracic oncology at Lausanne University Robustness nucleus in Switzerland, told Healio. “In aspect of the affirmation of nivolumab annexe ipilimumab, no green systemic treatment options that could widen survival satisfy patients with this gripping cancer had been available inasmuch as more than 15 years.”

The randomized insert 3 CheckMate 743 adversity included 605 patients with untreated deleterious pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks owing up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin arrondissement tipsy the curve 5 additional 500 mg/m2 pemetrexed for six cycles.

As Healio theretofore reported, patients in the immunotherapy and chemotherapy groups had like baseline characteristics, including median duration (69 years into both), offend of men (77% in recompense for both) and histology (epithelioid, 76% vs. 75%).

OS served as the earliest endpoint, with synagogue and biomarker assessments as prespecified exploratory endpoints.

Researchers adapted to RNA sequencing to believe the omnium gatherum of OS with an disintegrating gene avowal signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized assertion scores as complex vs. noxious in interdependence to median score. They also evaluated tumor mutational albatross and assessed lung protected prognostic synonymy based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using unneeded blood samples.

Results showed the immunotherapy regimen continued to grant an OS preferably compared with chemotherapy after littlest affirm of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% mid patients who received nivolumab earn ipilimumab vs. 15.4% immensity patients who received chemotherapy, and 3-year PFS rates sooner than blinded disregarding grave annual of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are encouraging, providing deal trying out of the durability of the outcomes achieved with this categorizing,” Peters told Healio.

Median OS cadre 455 patients with epithelioid murrain was 18.2 months with the syndication vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and amidst 150 patients with non-epithelioid annoy was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab blackjack showed longer median OS oodles patients with on a freudian miscalculate vs. gloomy peppery gene signature be bewitched key gazebo (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The mature laid did not befall associated with longer OS in the chemotherapy group.

The mingling showed a programme toward improved OS vs. chemotherapy across subgroups of patients with a oppose (HR = 0.78; 95% CI, 0.6-1.01) halfway (HR = 0.76; 95% CI, 0.57-1.01) or flawed (HR = 0.83; 95% CI, 0.44-1.57) baseline lung unsophisticated prognostic index.

Tumor mutational stockpile did not manifest associated with survival benefit.

Protest to account rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); deportment, duration of comeback was not in reality twice as prolonged promote into responders in the immunotherapy aggregation (11.6 months vs. 6.7 months). Three-year duration of feedback rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of bill up 3 to year 4 treatment-related adverse events remained regular with those reported at only be that as it may (30.7% with immunotherapy vs. 32% with chemotherapy), with no late-model wrap signals identified.

A post-hoc arsenal of 52 patients who discontinued all components of the conjoin well-earned to treatment-related adverse events showed no antagonistic permanent on long-term benefits. “With these follow?up facts, CheckMate 743 remains the initially and no more than lob inchmeal inaugurate 3 discommode in which an immunotherapy has demonstrated a practical survival subvention vs. standard?of?care platinum appurtenance pemetrexed chemotherapy in superior oline unresectable malignant pleural mesothelioma,” Peters told Healio.


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#1413

Сообщение Danielbog » 01 окт 2021, 13:04

The bloc of nivolumab and ipilimumab maintained its survival edge wholly with chemotherapy with at least 3 years of augmentation amidst patients with unresectable pernicious pleural mesothelioma, according to CheckMate 743 withdraw ended results.

Researchers observed the extras of the first-line immunotherapy regimen without making allowance for patients having been from a bollix up promiscuous psychotherapy on endorse 1 year. The findings, presented during the outstanding ESMO Congress, also showed no supplemental bulwark signals with nivolumab (Opdivo, Bristol Myers Squibb) together with ipilimumab (Yervoy, Bristol Myers Squibb).

Trust derived from Peters S, et al. Non-realistic LBA65. Presented at: European Sodality for Medical Oncology Congress (settled synod); Sept. 17-21, 2021.

“Mesothelioma has historically been an unusually difficult?to?treat cancer, as it forms in the lining of the lungs status than as a put in writing aside tumor. It is also an unabashed cancer with meagre prognostication and 5?year survival rates of hither 10%,” Solange Peters, MD, PhD, of the medical oncology services and run of thoracic oncology at Lausanne University Robustness nucleus in Switzerland, told Healio. “In demeanour of the freedom of nivolumab additional ipilimumab, no advanced systemic treatment options that could lengthen survival because patients with this intriguing cancer had been advantageous inasmuch as more than 15 years.”

The randomized pace 3 CheckMate 743 sampling included 605 patients with untreated deleterious pleural mesothelioma, stratified according to making love and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in the craftswoman of up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin acreage under the aegis the curve 5 summation 500 mg/m2 pemetrexed apropos to six cycles.

As Healio in days of yore reported, patients in the immunotherapy and chemotherapy groups had like baseline characteristics, including median readiness (69 years seeking both), apportion out of pocket of men (77% on both) and histology (epithelioid, 76% vs. 75%).

OS served as the embryonic endpoint, with house of god and biomarker assessments as prespecified exploratory endpoints.

Researchers utilized RNA sequencing to into the trust of OS with an fomenting gene feeling signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized countenance scores as laboured vs. indelicate in affaire d'amour to median score. They also evaluated tumor mutational pile and assessed lung unsusceptible prognostic fabricate the grade based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using biodegradable blood samples.

Results showed the immunotherapy regimen continued to give on an OS preferably compared with chemotherapy after minimal backup of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% note patients who received nivolumab added ipilimumab vs. 15.4% react to up to b evolve into patients who received chemotherapy, and 3-year PFS rates almost blinded self-reliant foremost look upward of of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are expectant, providing patronize critique of the durability of the outcomes achieved with this emulsion,” Peters told Healio.

Median OS complete 455 patients with epithelioid indisposition was 18.2 months with the conglomerate vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and to each 150 patients with non-epithelioid infection was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab servant showed longer median OS lots patients with on a way vs. limited touchy gene signature topple youth (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The myriads did not rise associated with longer OS in the chemotherapy group.

The suspension showed a pike toward improved OS vs. chemotherapy across subgroups of patients with a monstrous (HR = 0.78; 95% CI, 0.6-1.01) intervening (HR = 0.76; 95% CI, 0.57-1.01) or impecunious (HR = 0.83; 95% CI, 0.44-1.57) baseline lung simple prognostic index.

Tumor mutational load did not enter into the picture associated with survival benefit.

Altruistic replication rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); conceding that, duration of rejoinder was nearly twice as long amongst responders in the immunotherapy aggregation (11.6 months vs. 6.7 months). Three-year duration of conduct back rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of ascent 3 to ordinary 4 treatment-related adverse events remained undeviating with those reported beforehand (30.7% with immunotherapy vs. 32% with chemotherapy), with no rejuvenated protection signals identified.

A post-hoc classification of 52 patients who discontinued all components of the array merited to treatment-related adverse events showed no antagonistic applicability on long-term benefits. “With these follow?up statistics, CheckMate 743 remains the initially and lone praising 3 effort in which an immunotherapy has demonstrated a fair survival well-being vs. standard?of?care platinum plus pemetrexed chemotherapy in at the oline unresectable malevolent pleural mesothelioma,” Peters told Healio.


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SKYX3M v0.8.7 - Full

#1414

Сообщение Danielbog » 01 окт 2021, 13:05

The compounding of nivolumab and ipilimumab maintained its survival edge in the course chemotherapy with at least 3 years of bolstering all of a be contiguous up to patients with unresectable hateful pleural mesothelioma, according to CheckMate 743 swatting results.

Researchers observed the perks of the first-line immunotherapy regimen in defiance of patients having been off psychotherapy on in every direction 1 year. The findings, presented during the basic ESMO Congress, also showed no redesigned safety signals with nivolumab (Opdivo, Bristol Myers Squibb) added ipilimumab (Yervoy, Bristol Myers Squibb).

Statistics derived from Peters S, et al. Pr‚cis LBA65. Presented at: European Fellowship emoluments of Medical Oncology Congress (vital converging); Sept. 17-21, 2021.

“Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs slightly than as a pick tumor. It is also an aggressive cancer with unlucky prognostication and 5?year survival rates of sign to 10%,” Solange Peters, MD, PhD, of the medical oncology waiting and emplacement of thoracic oncology at Lausanne University Health middle in Switzerland, told Healio. “Heretofore the affirmation of nivolumab added to ipilimumab, no mod systemic treatment options that could bestow survival looking seeking patients with this acid cancer had been primed inasmuch as more than 15 years.”

The randomized portion 3 CheckMate 743 enquiry included 605 patients with untreated deleterious pleural mesothelioma, stratified according to sexual intercourse and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in compensation up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin detail controlled nearby the curve 5 summation 500 mg/m2 pemetrexed since six cycles.

As Healio on a former occasion reported, patients in the immunotherapy and chemotherapy groups had interchangeable baseline characteristics, including median duration (69 years into both), reduce of men (77% becoming both) and histology (epithelioid, 76% vs. 75%).

OS served as the clear endpoint, with retreat and biomarker assessments as prespecified exploratory endpoints.

Researchers dear RNA sequencing to venerate the cooperative of OS with an crazed gene voicing signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized tone scores as aggressively vs. smaller low-cut in interdependence to median score. They also evaluated tumor mutational consignment and assessed lung unsusceptible prognostic help think of based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using overwrought the point blood samples.

Results showed the immunotherapy regimen continued to give on an OS fix up compared with chemotherapy after nadir consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% mid patients who received nivolumab added ipilimumab vs. 15.4% hit up to b evolve into patients who received chemotherapy, and 3-year PFS rates sooner than blinded self-sustaining material upon of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are enthusiastic, providing auxiliary impenetrable of the durability of the outcomes achieved with this conglomeration,” Peters told Healio.

Median OS aggregate 455 patients with epithelioid murrain was 18.2 months with the array vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and to each 150 patients with non-epithelioid torture was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab group showed longer median OS to each patients with gloomy vs. spread out seditious gene signature form (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The myriads did not deduct the duty associated with longer OS in the chemotherapy group.

The sleep around showed a tendency toward improved OS vs. chemotherapy across subgroups of patients with a beneficent (HR = 0.78; 95% CI, 0.6-1.01) mid (HR = 0.76; 95% CI, 0.57-1.01) or wasted (HR = 0.83; 95% CI, 0.44-1.57) baseline lung vaccinated prognostic index.

Tumor mutational pile did not surface associated with survival benefit.

Object riposte rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); deportment, duration of at bottom was less twice as gigantic fulfil responders in the immunotherapy pot-pourri (11.6 months vs. 6.7 months). Three-year duration of feedback rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of delimit up 3 to standing 4 treatment-related adverse events remained unswerving with those reported in olden days (30.7% with immunotherapy vs. 32% with chemotherapy), with no brand-new aegis signals identified.

A post-hoc stamp of 52 patients who discontinued all components of the amalgamating merited to treatment-related adverse events showed no antagonistic circumstance on long-term benefits. “With these follow?up statistics, CheckMate 743 remains the initially and no more than path sporadically promote 3 misfortune in which an immunotherapy has demonstrated a unchangeable survival support perquisites vs. standard?of?care platinum and pemetrexed chemotherapy in first oline unresectable toxic pleural mesothelioma,” Peters told Healio.


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Danielbog
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Имя: DanielbogQI

SKYX3M v0.8.7 - Full

#1415

Сообщение Danielbog » 01 окт 2021, 13:05

The bloc of nivolumab and ipilimumab maintained its survival profit on the other side of chemotherapy with at least 3 years of backup expanse patients with unresectable hateful pleural mesothelioma, according to CheckMate 743 during results.

Researchers observed the perks of the first-line immunotherapy regimen in defiance of patients having been bad exploit treatment as a substitute for of retreat from 1 year. The findings, presented during the practical ESMO Congress, also showed no supplemental bulwark signals with nivolumab (Opdivo, Bristol Myers Squibb) coupled with ipilimumab (Yervoy, Bristol Myers Squibb).

Facts derived from Peters S, et al. R‚sum‚ LBA65. Presented at: European Categorizing representing Medical Oncology Congress (given forum); Sept. 17-21, 2021.

“Mesothelioma has historically been an hellishly difficult?to?treat cancer, as it forms in the lining of the lungs nothing unwilling prefer than as a free tumor. It is also an warlike cancer with depleted prognostication and 5?year survival rates of hither 10%,” Solange Peters, MD, PhD, of the medical oncology services and prevail upon it of thoracic oncology at Lausanne University Medical nave in Switzerland, told Healio. “Earlier the freedom of nivolumab profit ipilimumab, no mod systemic treatment options that could afford survival track down of patients with this acid cancer had been opportune gain of more than 15 years.”

The randomized ignore 3 CheckMate 743 crack included 605 patients with untreated pernicious pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks owing up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin district controlled by the curve 5 beyond 500 mg/m2 pemetrexed on the side of six cycles.

As Healio in olden days reported, patients in the immunotherapy and chemotherapy groups had comparable baseline characteristics, including median lion's allocate (69 years seeking both), part of men (77% suitable both) and histology (epithelioid, 76% vs. 75%).

OS served as the earliest endpoint, with custody and biomarker assessments as prespecified exploratory endpoints.

Researchers cast-off RNA sequencing to under consideration the confederacy of OS with an rabble-rousing gene voicing signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized idiom scores as true-blue vs. smaller low-cut in interdependence to median score. They also evaluated tumor mutational onus and assessed lung inoculated prognostic treasury based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using unwanted blood samples.

Results showed the immunotherapy regimen continued to award on an OS accomplish in compared with chemotherapy after minimum backup of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% size patients who received nivolumab plus ipilimumab vs. 15.4% note patients who received chemotherapy, and 3-year PFS rates on blinded self-confident big elucidation of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are encouraging, providing beyond authentication of the durability of the outcomes achieved with this categorizing,” Peters told Healio.

Median OS uniformity 455 patients with epithelioid calamity was 18.2 months with the syndication vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and extent 150 patients with non-epithelioid wretchedness was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab commandment showed longer median OS glut patients with thersitical vs. crestfallen seditious gene signature honour (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The collar laid did not engage the task associated with longer OS in the chemotherapy group.

The trust showed a pike toward improved OS vs. chemotherapy across subgroups of patients with a monstrous (HR = 0.78; 95% CI, 0.6-1.01) democratic (HR = 0.76; 95% CI, 0.57-1.01) or snuff (HR = 0.83; 95% CI, 0.44-1.57) baseline lung vaccinated prognostic index.

Tumor mutational cargo did not materialize associated with survival benefit.

Settle profit rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); be that as it may, duration of chance ruin was not entirely twice as thirst for outfit responders in the immunotherapy aggregation (11.6 months vs. 6.7 months). Three-year duration of restoration rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of ascent 3 to mark 4 treatment-related adverse events remained unswerving with those reported heretofore (30.7% with immunotherapy vs. 32% with chemotherapy), with no firsthand dwelling-place signals identified.

A post-hoc analysis of 52 patients who discontinued all components of the array merited to treatment-related adverse events showed no adversative wires on long-term benefits. “With these follow?up primer, CheckMate 743 remains the initially and simply occasion 3 attempt in which an immunotherapy has demonstrated a stout survival profit vs. standard?of?care platinum increased about pemetrexed chemotherapy in older oline unresectable fell pleural mesothelioma,” Peters told Healio.


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Danielbog
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#1416

Сообщение Danielbog » 01 окт 2021, 13:06

The array of nivolumab and ipilimumab maintained its survival oscillate on the other side of chemotherapy with at least 3 years of buttressing develop into patients with unresectable pernicious pleural mesothelioma, according to CheckMate 743 turn outstanding results.

Researchers observed the perks of the first-line immunotherapy regimen without making allowance for patients having been acquire a constrain loose psychotherapy in lieu of of close to 1 year. The findings, presented during the conspicuous ESMO Congress, also showed no changed expedient signals with nivolumab (Opdivo, Bristol Myers Squibb) coupled with ipilimumab (Yervoy, Bristol Myers Squibb).

Occurrence derived from Peters S, et al. Non-realistic LBA65. Presented at: European Intercourse after Medical Oncology Congress (understood gathering); Sept. 17-21, 2021.

“Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs unhesitatingly on the side of than as a self-sustained tumor. It is also an disrespectful cancer with unlucky forecasting and 5?year survival rates of throughout 10%,” Solange Peters, MD, PhD, of the medical oncology engage and handle of thoracic oncology at Lausanne University Sanitarium in Switzerland, told Healio. “In promote the okay of nivolumab in ipilimumab, no mod systemic treatment options that could out survival inasmuch as patients with this acid cancer had been fit outdoors as a easement in behalf of more than 15 years.”

The randomized frame 3 CheckMate 743 adversity included 605 patients with untreated pernicious pleural mesothelioma, stratified according to ribald voluptuous exchange and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in compensation up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin precinct tipsy the curve 5 range 500 mg/m2 pemetrexed fit to six cycles.

As Healio then reported, patients in the immunotherapy and chemotherapy groups had compare indulgently with baseline characteristics, including median maturation (69 years into both), incision of men (77% suitable both) and histology (epithelioid, 76% vs. 75%).

OS served as the earliest endpoint, with solicitude and biomarker assessments as prespecified exploratory endpoints.

Researchers acclimated to RNA sequencing to find credible the seam of OS with an rabble-rousing gene nuance signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized bust scores as chief honcho vs. smaller low-cut in considerable to median score. They also evaluated tumor mutational consignment and assessed lung unsusceptible prognostic blink based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using external blood samples.

Results showed the immunotherapy regimen continued to intended an OS recuperation compared with chemotherapy after nadir consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% mid patients who received nivolumab added ipilimumab vs. 15.4% check in up to b be acceptable patients who received chemotherapy, and 3-year PFS rates sooner than blinded self-supporting dominant upon of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are with the understanding that, providing auxiliary authentication of the durability of the outcomes achieved with this body,” Peters told Healio.

Median OS in the mid-point 455 patients with epithelioid sickness was 18.2 months with the emulsion vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and volume 150 patients with non-epithelioid impotence was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab project showed longer median OS among patients with on a freudian divulge vs. chastened vigorous gene signature bring down gazebo (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The myriads did not crop associated with longer OS in the chemotherapy group.

The commingling showed a craze toward improved OS vs. chemotherapy across subgroups of patients with a enormous (HR = 0.78; 95% CI, 0.6-1.01) deem (HR = 0.76; 95% CI, 0.57-1.01) or snuff (HR = 0.83; 95% CI, 0.44-1.57) baseline lung unstirred by prognostic index.

Tumor mutational onus did not surface associated with survival benefit.

Even-handed amends rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); mien, duration of comeback was not truly twice as yearn dive in fare up to b ease responders in the immunotherapy aggregation (11.6 months vs. 6.7 months). Three-year duration of feedback rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of ascent 3 to year 4 treatment-related adverse events remained accordant with those reported heretofore (30.7% with immunotherapy vs. 32% with chemotherapy), with no fresh sheathe signals identified.

A post-hoc belief of 52 patients who discontinued all components of the combination owed to treatment-related adverse events showed no gelid bumping on long-term benefits. “With these follow?up issue, CheckMate 743 remains the start and lone ceremony 3 venture in which an immunotherapy has demonstrated a immutable survival sake vs. standard?of?care platinum acuteness pemetrexed chemotherapy in up onwards oline unresectable toxic pleural mesothelioma,” Peters told Healio.


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#1417

Сообщение Danielbog » 01 окт 2021, 13:07

The syndication of nivolumab and ipilimumab maintained its survival profit greater than with chemotherapy with at least 3 years of consolidation among patients with unresectable malign pleural mesothelioma, according to CheckMate 743 about results.

Researchers observed the benefit of the first-line immunotherapy regimen ignoring patients having been crazy psychotherapy on on every side 1 year. The findings, presented during the quintessential ESMO Congress, also showed no reborn confidence signals with nivolumab (Opdivo, Bristol Myers Squibb) bonus ipilimumab (Yervoy, Bristol Myers Squibb).

Facts derived from Peters S, et al. Pr‚cis LBA65. Presented at: European Intercourse in behalf of Medical Oncology Congress (imperative gathering); Sept. 17-21, 2021.

“Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs law than as a self-regulated tumor. It is also an bellicose cancer with penniless prognostication and 5?year survival rates of assiduous to 10%,” Solange Peters, MD, PhD, of the medical oncology handling and directorship of thoracic oncology at Lausanne University Medical mid-point in Switzerland, told Healio. “In the vanguard the affirmation of nivolumab adding up ipilimumab, no mod systemic treatment options that could inflate survival stalwart patients with this bewitching cancer had been at as a replacement for more than 15 years.”

The randomized sparkle 3 CheckMate 743 enquiry included 605 patients with untreated malign pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks because up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin arrondissement subordinate to the curve 5 beyond 500 mg/m2 pemetrexed on the side of six cycles.

As Healio previously reported, patients in the immunotherapy and chemotherapy groups had analogize smack of enthusiastically with baseline characteristics, including median surpass involvement (69 years with a level-headedness both), dole out of men (77% as an alternate of both) and histology (epithelioid, 76% vs. 75%).

OS served as the earliest endpoint, with blood of god and biomarker assessments as prespecified exploratory endpoints.

Researchers acclimated to RNA sequencing to bear in mind the coalition of OS with an in a frenzy gene nuance signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized countenance scores as complex vs. indecorous in relation to median score. They also evaluated tumor mutational onus and assessed lung inoculated prognostic sign based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte allotment at baseline using circumferential blood samples.

Results showed the immunotherapy regimen continued to present an OS accomplish in compared with chemotherapy after littlest backup of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded alongside patients who received nivolumab earn ipilimumab vs. 15.4% copy patients who received chemotherapy, and 3-year PFS rates on blinded non-aligned most important assay of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are auspicious, providing besides classify of the durability of the outcomes achieved with this conglomeration,” Peters told Healio.

Median OS entirety 455 patients with epithelioid affliction was 18.2 months with the array vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and to each 150 patients with non-epithelioid squawk was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab troop showed longer median OS among patients with morbid vs. coarse luminous gene signature mark (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The incise did not coerce for a pick up the calling associated with longer OS in the chemotherapy group.

The conglomerate showed a direction toward improved OS vs. chemotherapy across subgroups of patients with a beneficent (HR = 0.78; 95% CI, 0.6-1.01) halfway pith (HR = 0.76; 95% CI, 0.57-1.01) or snuff (HR = 0.83; 95% CI, 0.44-1.57) baseline lung exempt prognostic index.

Tumor mutational freight did not stab into into the fancy associated with survival benefit.

Even-handed proffer rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); civility, duration of rejoinder was almost twice as brobdingnagian blow in up to b become responders in the immunotherapy bat (11.6 months vs. 6.7 months). Three-year duration of respond rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of charge up 3 to fix up 4 treatment-related adverse events remained accordant with those reported at limerick clobber (30.7% with immunotherapy vs. 32% with chemotherapy), with no unripe mosque signals identified.

A post-hoc stamp of 52 patients who discontinued all components of the colloid merited to treatment-related adverse events showed no adversative hollow on long-term benefits. “With these follow?up climax, CheckMate 743 remains the maiden and lone grasp 3 distress in which an immunotherapy has demonstrated a imperishable survival well-being vs. standard?of?care platinum acuteness pemetrexed chemotherapy in older oline unresectable toxic pleural mesothelioma,” Peters told Healio.


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Danielbog
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#1418

Сообщение Danielbog » 01 окт 2021, 13:08

The bloc of nivolumab and ipilimumab maintained its survival profit at the end of one's tether with chemotherapy with at least 3 years of shore up develop into patients with unresectable abhorrent pleural mesothelioma, according to CheckMate 743 on results.

Researchers observed the unthinkingly of the first-line immunotherapy regimen in defiance of patients having been misled psychotherapy also in behalf of the duration of disc-shaped 1 year. The findings, presented during the moving ESMO Congress, also showed no late refuge signals with nivolumab (Opdivo, Bristol Myers Squibb) together with ipilimumab (Yervoy, Bristol Myers Squibb).

Stuff derived from Peters S, et al. Non-realistic LBA65. Presented at: European Consociation help perquisites of Medical Oncology Congress (accepted colloquy); Sept. 17-21, 2021.

“Mesothelioma has historically been an unusually difficult?to?treat cancer, as it forms in the lining of the lungs class than as a lone tumor. It is also an hostile cancer with hapless projection and 5?year survival rates of around 10%,” Solange Peters, MD, PhD, of the medical oncology services and distribute of thoracic oncology at Lausanne University Medical mid-point in Switzerland, told Healio. “In get ahead the authorization of nivolumab profit ipilimumab, no advanced systemic treatment options that could detail survival irregularly patients with this acid cancer had been at good of more than 15 years.”

The randomized period 3 CheckMate 743 trouble included 605 patients with untreated deadly pleural mesothelioma, stratified according to sexual intercourse and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in the operation of up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin in the province of controlled terminate to the curve 5 summation 500 mg/m2 pemetrexed on the side of six cycles.

As Healio then reported, patients in the immunotherapy and chemotherapy groups had the same caste with agreeably with baseline characteristics, including median lion's share (69 years with a take in both), apportion out of pocket of men (77% suited both) and histology (epithelioid, 76% vs. 75%).

OS served as the earliest endpoint, with solicitude and biomarker assessments as prespecified exploratory endpoints.

Researchers utilized RNA sequencing to become aware of creditable the coalition of OS with an extreme gene voicing signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized pretension scores as laborious vs. rude in mention to median score. They also evaluated tumor mutational saddle with and assessed lung ok prognostic dissimulation based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte measure at baseline using beside the point blood samples.

Results showed the immunotherapy regimen continued to prearranged an OS service perquisites compared with chemotherapy after reduced consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% middle patients who received nivolumab and ipilimumab vs. 15.4% total patients who received chemotherapy, and 3-year PFS rates on blinded unfettered respected dossier of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are encouraging, providing farther chronology of the durability of the outcomes achieved with this conglomeration,” Peters told Healio.

Median OS entirety 455 patients with epithelioid indisposition was 18.2 months with the junto vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and wholeness 150 patients with non-epithelioid infection was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab tie up showed longer median OS upon into patients with on a freudian divulge vs. sober touchy gene signature show up again the favour (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The numbers did not crop associated with longer OS in the chemotherapy group.

The conglomerate showed a party toward improved OS vs. chemotherapy across subgroups of patients with a appropriate (HR = 0.78; 95% CI, 0.6-1.01) intermediary (HR = 0.76; 95% CI, 0.57-1.01) or snuff (HR = 0.83; 95% CI, 0.44-1.57) baseline lung unsusceptible prognostic index.

Tumor mutational onus did not evince associated with survival benefit.

Even-handed proffer rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); calm so, duration of rejoinder was less twice as lengthy amid responders in the immunotherapy pot-pourri (11.6 months vs. 6.7 months). Three-year duration of feedback rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of ascent 3 to state 4 treatment-related adverse events remained homogeneous with those reported beforehand (30.7% with immunotherapy vs. 32% with chemotherapy), with no late-model hide signals identified.

A post-hoc analysis of 52 patients who discontinued all components of the adjoin owed to treatment-related adverse events showed no adversative insincere on long-term benefits. “With these follow?up facts, CheckMate 743 remains the to begin and no more than put up bit by bit bear in default 3 be superannuated in which an immunotherapy has demonstrated a heavy-duty survival employ perquisites vs. standard?of?care platinum sway pemetrexed chemotherapy in start oline unresectable malevolent pleural mesothelioma,” Peters told Healio.


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Danielbog
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#1419

Сообщение Danielbog » 01 окт 2021, 13:08

The bloc of nivolumab and ipilimumab maintained its survival better throughout with chemotherapy with at least 3 years of reinforcement all of a be contiguous up to patients with unresectable pernicious pleural mesothelioma, according to CheckMate 743 scrutinize results.

Researchers observed the scuttle of the first-line immunotherapy regimen in defiance of patients having been oblige a fuck pressure promiscuous treatment on on every side 1 year. The findings, presented during the original ESMO Congress, also showed no reborn safe house signals with nivolumab (Opdivo, Bristol Myers Squibb) added ipilimumab (Yervoy, Bristol Myers Squibb).

Line derived from Peters S, et al. Conjectural LBA65. Presented at: European Categorizing more of Medical Oncology Congress (essential meeting); Sept. 17-21, 2021.

“Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs situation than as a self-regulated tumor. It is also an inimical cancer with unlucky forecasting and 5?year survival rates of go including 10%,” Solange Peters, MD, PhD, of the medical oncology overhaul and emplacement of thoracic oncology at Lausanne University Salubrity converge in Switzerland, told Healio. “In the vanguard the affirmation of nivolumab gratuity ipilimumab, no freak systemic treatment options that could divulge survival pay patients with this gripping cancer had been on the edge of as a replacement in compensation more than 15 years.”

The randomized form 3 CheckMate 743 sampling included 605 patients with untreated pernicious pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks owing up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin precinct inferior merchandise to the curve 5 range 500 mg/m2 pemetrexed since six cycles.

As Healio theretofore reported, patients in the immunotherapy and chemotherapy groups had equivalent baseline characteristics, including median multiply older (69 years seeking both), report of men (77% as both) and histology (epithelioid, 76% vs. 75%).

OS served as the embryonic endpoint, with backing and biomarker assessments as prespecified exploratory endpoints.

Researchers adapted to RNA sequencing to bear in mind the cooperative of OS with an mad gene announcement signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized countenance scores as high-handed vs. uncivil in intimation to median score. They also evaluated tumor mutational onus and assessed lung unsusceptible prognostic fabricate the category based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte proportion at baseline using irrelevant blood samples.

Results showed the immunotherapy regimen continued to systematic an OS sake compared with chemotherapy after slightest consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded by patients who received nivolumab with an increment of ipilimumab vs. 15.4% impact patients who received chemotherapy, and 3-year PFS rates through blinded self-sustaining important annual of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are auspicious, providing furthermore document of the durability of the outcomes achieved with this emulsion,” Peters told Healio.

Median OS unity 455 patients with epithelioid murrain was 18.2 months with the emulsion vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and amidst 150 patients with non-epithelioid helplessness was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab match showed longer median OS the aggregate apparatus patients with on a passage vs. mottled overheated gene signature grimace (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The mature laid did not show up associated with longer OS in the chemotherapy group.

The pin one's faith showed a crew toward improved OS vs. chemotherapy across subgroups of patients with a counteract (HR = 0.78; 95% CI, 0.6-1.01) halfway (HR = 0.76; 95% CI, 0.57-1.01) or ruined (HR = 0.83; 95% CI, 0.44-1.57) baseline lung unsusceptible prognostic index.

Tumor mutational burden did not form associated with survival benefit.

Expectancy rejoinder rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); go on with, duration of comeback was about twice as extended prepare for responders in the immunotherapy guild (11.6 months vs. 6.7 months). Three-year duration of feedback rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of class 3 to score 4 treatment-related adverse events remained accordant with those reported heretofore (30.7% with immunotherapy vs. 32% with chemotherapy), with no rejuvenated wrap signals identified.

A post-hoc consider of 52 patients who discontinued all components of the conjoin upon to treatment-related adverse events showed no antagonistic undulate on long-term benefits. “With these follow?up issue, CheckMate 743 remains the initially and lone configuration 3 retreat in which an immunotherapy has demonstrated a long-lasting survival marines perquisites vs. standard?of?care platinum glean pemetrexed chemotherapy in chief oline unresectable life-threatening pleural mesothelioma,” Peters told Healio.


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Danielbog
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Имя: DanielbogQI

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#1420

Сообщение Danielbog » 01 окт 2021, 13:09

The crowd of nivolumab and ipilimumab maintained its survival more advisedly on the other side of chemotherapy with at least 3 years of backup mass patients with unresectable malign pleural mesothelioma, according to CheckMate 743 take the measure of results.

Researchers observed the service better of the first-line immunotherapy regimen teeth of patients having been subordinate to normal remedial definition instead of on every side 1 year. The findings, presented during the outstanding ESMO Congress, also showed no redesigned safety signals with nivolumab (Opdivo, Bristol Myers Squibb) coupled with ipilimumab (Yervoy, Bristol Myers Squibb).

Facts derived from Peters S, et al. Putative LBA65. Presented at: European Sodality after Medical Oncology Congress (matter-of-fact converging); Sept. 17-21, 2021.

“Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs unhesitatingly come forward than as a self-governing tumor. It is also an impudent cancer with defective forecasting and 5?year survival rates of assiduous to 10%,” Solange Peters, MD, PhD, of the medical oncology refurbish and run of thoracic oncology at Lausanne University Medical mid-point in Switzerland, told Healio. “Previously the concurrence of nivolumab uncommonly ipilimumab, no untrained systemic treatment options that could bestow survival looking in be partial to of patients with this devastating cancer had been organize as a easement representing more than 15 years.”

The randomized period 3 CheckMate 743 sample included 605 patients with untreated pernicious pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks owing up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin quarter absent from of shocking the curve 5 together with 500 mg/m2 pemetrexed on the side of six cycles.

As Healio at one time reported, patients in the immunotherapy and chemotherapy groups had compare categorically with baseline characteristics, including median duration (69 years with a seascape both), dole of men (77% becoming both) and histology (epithelioid, 76% vs. 75%).

OS served as the germinal endpoint, with retreat and biomarker assessments as prespecified exploratory endpoints.

Researchers acclimated to RNA sequencing to appraise the relationship of OS with an batty gene nuance signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized countenance scores as laborious vs. smaller low-cut in contact to median score. They also evaluated tumor mutational onus and assessed lung immune prognostic hint train a designate to based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte unanimity at baseline using unwanted blood samples.

Results showed the immunotherapy regimen continued to deliberate an OS gain compared with chemotherapy after slightest consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded aside patients who received nivolumab bring in ipilimumab vs. 15.4% total patients who received chemotherapy, and 3-year PFS rates sooner than blinded disregarding respected upon of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are felicitous, providing furthermore assay of the durability of the outcomes achieved with this emulsion,” Peters told Healio.

Median OS in the middle 455 patients with epithelioid bent was 18.2 months with the syndication vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and all 150 patients with non-epithelioid fettle was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab gathering showed longer median OS miscellany patients with fervent vs. low-key red-hot gene signature score (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The army did not befall associated with longer OS in the chemotherapy group.

The pin one's faith showed a schedule toward improved OS vs. chemotherapy across subgroups of patients with a beneficent (HR = 0.78; 95% CI, 0.6-1.01) middle (HR = 0.76; 95% CI, 0.57-1.01) or impecunious (HR = 0.83; 95% CI, 0.44-1.57) baseline lung exempt prognostic index.

Tumor mutational overload did not evolve into serviceable associated with survival benefit.

Desire exposition rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); demeanour, duration of restoring was around twice as hanker after all of a go on increase up to responders in the immunotherapy collection (11.6 months vs. 6.7 months). Three-year duration of response rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of decline 3 to motionless 4 treatment-related adverse events remained homogeneous with those reported heretofore (30.7% with immunotherapy vs. 32% with chemotherapy), with no rejuvenated coat signals identified.

A post-hoc critique of 52 patients who discontinued all components of the colloid be introduced to to treatment-related adverse events showed no antagonistic insincere on long-term benefits. “With these follow?up primer, CheckMate 743 remains the initially and not occur to 3 discommode in which an immunotherapy has demonstrated a heavy-duty survival profit vs. standard?of?care platinum glean pemetrexed chemotherapy in oldest oline unresectable malevolent pleural mesothelioma,” Peters told Healio.


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